Uterine myomata and outcome of assisted reproduction.
نویسندگان
چکیده
The aim of this work was to study the effect of uterine myomata on the implantation rate and outcome in in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Among 406 patients, 51 (12.6%) were found to have uterine corporeal myomata. Twelve patients were excluded from the study as they had large myomata, submucous myomata or intramural myomata encroaching on the cavity. These patients were advised to have myomectomy before being enrolled in the IVF/ICSI programme. The remaining patients (n = 39) were sorted according to the number, site and size of the myomata as assessed by transvaginal sonography. Three patients had more than one myoma. Most of the myomata were subserous (72.7%) and the mean diameter of the myomata was 3.5 +/- 0.9 cm. A control group (n = 367) was chosen with normal uteri and no history of uterine reconstruction surgery. The mean age of myoma patients was 34.7 +/- 3.6 years as compared to 34.0 +/- 4.4 years in the control group. The age, period of infertility, body mass index, duration and number of human menopausal gonadotrophin ampoules needed for stimulation, oestradiol levels, number of oocytes retrieved and the fertilization rate were not significantly different in the myoma patients compared to the control group. Fifteen myoma patients (38.5%) subsequently showed one or more pregnancy sacs on ultrasonography of which three (20%) spontaneously aborted during the first trimester and two (13.3%) had preterm labour, as compared to 123 (33.5%), 19 (15.5%) and nine (7.3%) respectively, among the control group (P = 0.27, 0.33 and 0.21). In conclusion, uterine corporeal myomata, not encroaching on the cavity and <7 cm in mean diameter, do not affect the implantation or miscarriage rates in IVF or ICSI.
منابع مشابه
Maternal Exposure to Second-hand Smoke and Super Ovulati on Outcome for Assisted Reproduction
Background The effect of smoking cigarettes is followed by diverse effects on ovaries and developing follicles but the effect of passive smoking on ovarian function is unknown. On the other hand, the ovarian response to induction is a very important step in assisted reproduction. The aim of this study is to compare ovarian response in passive smokers and non-passive smokers in an assisted repro...
متن کاملComputed tomography angiogram for failed uterine artery embolization.
It was the aim of this study to discuss the efficacy of computed tomography angiography after failed uterine artery embolization. We performed a review of cases where embolization of myomata failed to relieve symptoms, or shrink myomata. If MRI showed continued uptake, patients were offered CT angiograms to better direct therapy. Repeat embolization details were compared with findings on CT ang...
متن کاملEndometrial changes associated with myomata of the uterus.
The endometrium of 30 uteruses with myomata was studied at four standard sites. Glandular atrophy over a myoma or opposite a myoma was the most constant finding. At the margin of a myoma hyperplastic glands were frequently found, and distorted, elongated, or dilated glands were present at this site in half of all specimens. Other changes included adenomyosis and the separation of glands by musc...
متن کاملReproductive Outcome following Hysteroscopic Monopolar Metroplasty: An Analysis of 203 Cases
متن کامل
Natural Size Development of Myomata - Ultrasound Observational Study of 55 Premenopausal Patients.
Objective: The natural growth progression of uterine leiomyomata will be studied and used to identify potential predictive criteria of myoma size development. This should answer the question of whether myoma growth is dependent on patient age, or on the localisation or original size of the myoma, as well as how much of a size increase can be expected per unit of time, and the proportion of myom...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Human reproduction
دوره 13 1 شماره
صفحات -
تاریخ انتشار 1998